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North Yorkshire Police said the case remained open. The force said one line of inquiry relating to a DNA profile would take a further six weeks, after which the active investigation would cease. Miss Lawrence's family has been informed the review had reached its conclusion, the force said. 'Worked tirelessly' Assistant Chief Constable Paul Kennedy said: "It is not for the want of trying that a breakthrough has not yet come, but rather the result of the continuing refusal of those who know what happened to Claudia to come forward and tell us the truth." Mr Kennedy said new lines of inquiry in what was an "extremely challenging and complex case" had been pursued with "vigour and determination". Image copyright PA Image caption Miss Lawrence's father Peter reported her missing after she failed to meet a friend for a drink "The case will not be closed until those responsible for Claudia's disappearance and, we believe, her murder, are brought to justice. "While the current review team will and has been scaled down, the new Cleveland and North Yorkshire cold case dedicated team will still have responsibility to review any information that is considered relevant," he added. The last contact anyone had with Miss Lawrence, who worked at the University of York, was when she spoke to her mother by phone on the 18 March 2009. She failed to attend work the following day and was later reported missing. Det Supt Dai Malyn, who led the review, said: "I acknowledge how sad Claudia's parents and sister feel that we have been unable to give them the answers they want, and everyone in the team shares their frustration.